N-Methyl-Pyrrolidone (NMP)

What is N-Methyl-Pyrrolidone (NMP)?

Molecular Formula (N-Methyl-Pyrrolidone (NMP)): C₅H₉NO

Molecular Weight: 99.13 g/mol

Chemical Name: N-Methyl Pyrrolidone

CAS Number: 872-50-4

This compound is a nitrogen-bound immunomodulator and antimyeloma compound. It is a common solvent acting as a solvent. It is also a pharmaceutical raw material.

In addition, it is a powerful solvent with wide solubility and high stability for resins. It is a volatile organic compound.

Other Names are as Follows;

• NMP
• N-Methyl Pyrrolidone
• 872-50-4
• 1-Methyl-Pyrrolidone
• Methyl Pyrrolidone
• Methyl Pyrrolidone
• N-Methyl-2-Pyrrolidone
• N-Methyl-2-Pyrrolidone
• N-Methylpyrrolidinone
• N-Methyl-2-Pyrrolidinone
• 1-Methyl-Pyrrolidin-2-one
• 1-Methylpyrrolidin-2-one

How is it Produced?

It is produced by the reaction of butyrolactone with methylamine. Other processes include preparation by the formulation of maleic and succinic acid solutions.

What are the Physical and Chemical Properties?

N-Methylpyrrolidone has aprotic properties. N-Methyl-2-Pyrrolidone is a colorless compound. It has an odor slightly resembling Amine.

N-Methyl Pyrrolidone is a stable chemical in terms of stability. However, it can undergo some reactions on its own.

The boiling point is 204 °C.

Melting Point: -24 °C.

Its density is around 1.034 g/cm³.

N-Methyl has the property of being very miscible in water in terms of solubility. It is soluble and very miscible in Ethanol, Acetone, Halogenated Hydrocarbons, and esters.

While having low volatility, it possesses high polarity in return.

It has slightly toxic properties.

N-Methyl-Pyrrolidone (NMP) (N-Methylpyrrolidone) has very strong hygroscopic properties.

What are the Usage Areas of N-Methyl-Pyrrolidone (NMP)?

• It is used as a drug solvent and penetration enhancer in dosage forms for humans and animals.
• In transdermal drug formulas, it increases the permeability of the skin for a short time to ensure the drug is absorbed more quickly. In such applications, Propylene Glycol, Ethyl Alcohol, N-Dimethylformamide, and N-Methyl-2-Pyrrolidone are used as penetration enhancing agents.
• It is a versatile industrial solvent.
• It is used for the extraction of aromatic hydrocarbons from lubricating oils.
• Among its usage areas, it is a common co-solvent used in the creation of water-based polyurethane dispersions.
• It assists in the processing of PUDs and the formation of the applied polyurethane film coating.
• In addition, it helps with substrate wetting, freeze/thaw stability, and adhesion to some substrates, while also serving as a microbicide in wet phases.
• N-Methylpyrrolidone is used in ammonia generators to remove carbon dioxide.
• It is used as a good solvent in polymerization reactions and polymers.
• It is used as an effective paint stripper.
• It is used in the production of pesticides.
• In pharmaceutical applications, it is used as a penetration enhancer for faster substance transfer through the skin.
• It is used in the production of weak amine gas scrubbing solutions. It is absorbed by amine solutions coming from the reverse direction to prevent acidic impurities.
• It is a chemical used as a solvent in gas separation and desulfurization processes in the petroleum sector.
• The most important aspect while performing petroleum industry activities is the separation of the Sulfur element, which is an impurity in oil. This is carried out with N-Methyl Pyrrolidone.

What are the Factors Affecting Its Prices?

The price of N-Methyl-Pyrrolidone is directly dependent on the prices of the chemical substances used in the production of N-Methylpyrrolidone. As methylamine prices increase, the price of N-Methylpyrrolidone will increase.

Prices are directly dependent on the stocks of companies selling N-Methylpyrrolidone. As N-Methyl-Pyrrolidone stocks increase, the price of N-Methyl-Pyrrolidone will increase.

N-Methylpyrrolidone prices increase with the increase in usage areas. This is because the produced N-Methylpyrrolidone will not meet the demanded quantity of N-Methyl-Pyrrolidone. This will directly pull N-Methyl-Pyrrolidone (NMP) (N-Methylpyrrolidone) prices upward.

The price is directly dependent on the number of companies producing N-Methylpyrrolidone. When the number of N-Methyl-Pyrrolidone (NMP) (N-Methylpyrrolidone) manufacturers increases, the price of N-Methyl-Pyrrolidone (NMP) (N-Methylpyrrolidone) will decrease because N-Methyl-Pyrrolidone (NMP) (N-Methylpyrrolidone) stocks will increase.